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Research & Development

Research Area

With an aim to improving patient’s QOL, Hitachi will continue to pursue the potential of medical equipment.

Conference Presentations

2023

AAPM A Motion Model Approach for Real-Time Markerless Tumor Tracking Ling Fung Cheung, Shinichirou Fujitaka, Takaaki Fujii, Naoki Miyamoto*1 and Seishin Takao*1
PTCOG-AO Towards online adaptive proton therapy: Research topics in Hokkaido University Koichi Miyazaki
FRPT IN-SILICO APPLICABILITY EVALUATION OF NEWLY DEVELOPED VARIABLE-ENERGY ACCELERATOR WITH A FIXED MAGNETIC FIELD FOR ULTRA-HIGH DOSE RATE IRRADIATION OF PROTON BEAMS Takuto Miyoshi, Takamichi Aoki, Futaro Ebina, Takuya Nomura, Koji Matsuda and Masumi Umezawa
*1
Hokkaido University

2022

CAARI & SNEAP Beam Delivery Tuning and Capability Estimation of Hitachi Synchrotron-based Particle Beam Treatment Systems for Ultra-high Dose Rate Radiotherapy Takuto Miyoshi, T. Nomura, K. Matsuda, H. Ogino*1, H. Iwata*1, T. Toshito*1, C. Omachi*1, M. Yagi*2, S. Shimizu*2, N. Hamatani*3, T. Tsubouchi*3, M. Takashina*3, K. Ogawa*2, T. Kanai*3, M. Umezawa
FRPT BEAM-DELIVERY TUNING OF HITACHI’S SYNCHROTRON-BASED SCANNING-TREATMENT SYSTEMS FOR PROTON/CARBON-ION ULTRA-HIGH-DOSE RATE (FLASH) IRRADIATION Takuto Miyoshi, T. Nomura, K. Matsuda, H. Ogino*1, H. Iwata*1, T. Toshito*1, C. Omachi*1, M. Yagi*2, S. Shimizu*2, N. Hamatani*3, T. Tsubouchi*3, M. Takashina*3, K. Ogawa*2, T. Kanai*3, M. Umezawa
*1
Nagoya City University West Medical Center
*2
Osaka University Graduate School of Medicine
*3
Osaka Heavy Ion Therapy Center

2021

AAPM Histogram analysis method of water equivalent path length to evaluate dose variation due to anatomical change in spot-scanning proton beam therapy Takaaki Fujii, Seishin Takao*1, Taeko Matsuura*1, Shusuke Hirayama, Naoki Miyamoto*1, Kikuo Umegaki*1, Shinichi Shimizu*1, Hiroki Shirato*1
PTCOG Development of scanning magnet with distributed winding coils for particle beam therapy Takahiro Yamada, Kazuya Nagashima, Takuya Nomura, Seiji Soeda, Noriaki Hino
PTCOG Hitachi Particle Therapy Solution and Synchrotron-based Ultra-High Dose irradiation (FLASH) capability Hiromitsu Iwata*2, Masumi Umezawa
PTCOG-NA Accurate beam model and dose calculation algorithm for carbon ion radiotherapy under magnetic field toward adaptive particle radiotherapy Takuto Miyoshi, Taisuke Takayanagi, Shinichiro Fujitaka
Scientific Meeting of the Japan Society of Medical Physics Feasibility study of MRI-guided proton therapy system Yusuke Fujii, Hideaki Ueda*1, Taisuke Takayanagi, Kikuo Umegaki*1, Taeko Matsuura*1
AAPM Development of An Irradiation System for MRI-Guided Proton Therapy Yusuke Fujii, Hideaki Ueda*1, Taisuke Takayanagi, Kikuo Umegaki*1, Taeko Matsuura*1
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2020

AAPM Resonant ionoacoustic measurement under clinical dose: A study toward online range verification Taisuke Takayanagi, Tomoki Uesaka*1, Yuta Nakamura*1, Mehmet Burcin Unlu*1, Yasutoshi Kuriyama*5, Yoshihiro Ishi*5, Tomonori Uesugi*5, Nobuki Kudo*1, Masanori Kobayashi*6, Kikuo Umegaki*1, Taeko Matsuura*1
PTCOG Measurement of resonant ionoacoustic waves in fixed-field alternating gradient accelerator for particle beam range verification Taisuke Takayanagi, Tomoki Uesaka*1, Yuta Nakamura*1, Mehmet Burcin Unlu*1, Yasutoshi Kuriyama*5, Yoshihiro Ishi*5, Tomonori Uesugi*5, Nobuki Kudo*1, Masanori Kobayashi*6, Kikuo Umegaki*1, Taeko Matsuura*1
AAPM Development of energy layer optimization considering minimum MU constraint for single field optimization in spot-scanning proton therapy Shusuke Hirayama, Shinichiro Fujitaka, Toru Umekawa, Rintaro Fujimoto, Yoshihiko Nagamine, Masahiro Hosaka, Toshiyuki Toshito*2, Kensuke Hayashi*2, Hiroyuki Ogino*2
Particle Accelerator Society of Japan ANALYSIS OF BEAM EXTRACTION IN MODULATED FREQUENCY VARIABLE ENERGY ACCELERATOR Yuto Nakashima, Takamichi Aoki, Toshimitsu Hae, Takayoshi Seki, Kenji Miyata, Chishin Hori, Kento Nishida, Fumiaki Noda, Futaro Ebina, Kazuo Hiramoto
Particle Accelerator Society of Japan DEVELOPMENT OF MAGNET DESIGN METHOD FOR COTANGENTIAL TRAJECTORY ACCELERATOR Kento Nishida, Chishin Hori, Takamichi Aoki, Toshimitsu Hae
The 34th Annual Meeting of Japan High-Precision External Beam Radiotherapy Group Update on Hitachi Particle Therapy System Masumi Umezawa, Chihiro Nakashima, Rintaro Fujimoto
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2019

PTCOG-NA Evaluation of accumulated dose distribution utilizing log data on spot scanning proton therapy for liver tumors T. Yamada, S. Takao*1, T. Matsuura, H. Koyano*1, H. Nihongi, Y. Fujii, S. Hirayama, K. Umegaki*1, N. Katoh, S. Shimizu*1, H. Shirato*1
Scientific Meeting of the Japan Society of Medical Physics Simulation studies of a proton range-verification method using ionoacoustic waves generated from spherical gold fiducials Taisuke Takayanagi, Tomoki Uesaka*1, Kikuo Umegaki*1, Hiroki Shirato*1, Taeko Matsuura*1
PTCOG Development of a proton range-verification method using ionoacoustic waves generated from spherical metal markers Taisuke Takayanagi, Tomoki Uesaka*1, Yuta Nakamura*1, Mehmet Burcin Unlu*1, Yasuto Kuriyama*5, Tomonori Uesugi*5, Yoshihiro Ishi*5, Kikuo Umegaki*1, Hiroki Shirato*1, Taeko Matsuura*1
Scientific Meeting of the Japan Society of Medical Physics Physical dose modelling and calculation results for carbon beam scanning in Osaka heavy ion therapy center Yusuke Fujii, Shinichiro Fujitaka, Hideaki Nihongi, Satoshi Nakayama, Masaaki Takashina*3, Noriaki Hamatani*3, Toshiro Tsubouchi*3, Masashi Yagi*3, Tatsuaki Kanai*3
Particle Accelerator Society of Japan DEVELOPMENT AND IMPLEMENTATION OF COMPACT ACCELERATOR SYSTEMS DEDICATED FOR PROTON BEAM THERAPY Futaro Ebina, Takamichi Aoki
Particle Accelerator Society of Japan OPTICAL DESIGN OF A WEAK-FOCUSING ACCELERATOR WITH HILLS AND VALLEYS Chishin Hori, Takamichi Aoki, Toshimitsu Hae, Takayoshi Seki
Particle Accelerator Society of Japan Study on slow extraction system in cotangential trajectory accelerator Takamitsu Hae, Takamichi Aoki, Chishin Hori, Yuto Nakashima, Fumiaki Noda, Takayoshi Seki, Kazuo Hiramoto
Int. Conf. on Cyclotrons and their Applications, Cyclotrons2019 OPTICAL DESIGN OF AVF WEAK-FOCUSING ACCELERATOR Chishin Hori, Takamichi Aoki, Takamitu Hae, Takayoshi Seki, Kazuo Hiramoto
Int. Conf. on Cyclotrons and their Applications, Cyclotrons2019 Compact Cotangential Orbit Accelerator for Proton Therapy Takamitsu Hae, Takamichi Aoki, Chishin Hori, Yuto Nakashima, Fumiaki Noda, Takayoshi Seki, Kazuo Hiramoto
Scientific Meeting of the Japan Society of Medical Physics Development of a system to support intra-fractional clinical decision for real-time image-gated proton therapy – (1) Automatic actual-dose calculation system Shusuke Hirayama, Taeko Matsuura*1, Keiji Kobashi*1, Hidenori Koyano*1, Takaaki Fujii, Seishin Takao*1, Naoki Miyamoto*1, Kikuo Umegaki*1, Hiroki Shirato*1, Shinichi Shimizu*1
Particle Accelerator Society of Japan SIMULATION OF SLOW EXTRACTION FROM COTANGENTIAL TRAJECTORY ACCELERATOR Takamichi Aoki, Toshimitsu Hae, Takayoshi Seki, Yuto Nakashima, Chishin Hori
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2018

PTCOG Development of Time Saving Daily QA Measurement Tool for Spot scanning system Takahiro Yamada, Taisuke Takayanagi, Seishin Takao*1, Taeko Matsuura*1, Shusuke Hirayama, Takaaki Fujii, Kikuo Umegaki*1
Scientific Meeting of the Japan Society of Medical Physics Lateral profile validation procedure utilizing simplified Monte Carlo calculation based on log data for patient specific QA of proton beam therapy Takahiro Yamada, Taisuke Takayanagi, Rintaro Fujimoto, Seishin Takao*1, Keiji Kobashi*1, Shinichi Shimizu*1, Kikuo Umegaki*1, Hiroki Shirato*1
Particle Accelerator Society of Japan BEAM COMMISSIONING AT OSAKA HEAVY ION THERAPY CENTER Fumiaki Noda, Futaro Ebina, Yuto Nakashima, Kento Miyahara, Takuya Nomura, Satoshi Tootake
Scientific Meeting of the Japan Society of Medical Physics 4D CBCT technique with fiducial marker position to reconstruct a volumetric image just before the treatment proton beam delivery in Real time image Gated Proton Therapy Takaaki Fujii, Seishin Takao*1, Shinichi Shimizu*1, Taeko Matsuura*1, Naoki Miyamoto*1, Shusuke Hirayama, Kikuo Umegaki*1, Hiroki Shirato*1
Particle Accelerator Society of Japan STUDY OF TRANSVERSE MOTION IN COTANGENTIAL TRAJECTORY ACCELERATOR Takamichi Aoki, Toshimitsu Hae, Takayoshi Seki, Yuto Nakashima, Chishin Hori
IPAC Betatron Frequencies in Cotangential Trajectory Accelerator for Proton Beam Therapy Takamichi Aoki, Toshimitsu Hae, Chishin Hori, Takayoshi Seki, Futaro Ebina
IPAC Development of 6d Particle Tracking Code for Particle Therapy System Yuto Nakashima, Kenji Miyata
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2017

Scientific Meeting of the Japan Society of Medical Physics Development of Time Saving Daily QA Measurement Tool for Spot Scanning Proton Therapy System Takahiro Yamada, Taisuke Takayanagi, Seishin Takao*1, Taeko Matsuura*1, Shusuke Hirayama, Takaaki Fujii, Kikuo Umegaki*1
Scientific Meeting of the Japan Society of Medical Physics Time saving lateral profile validation procedure utilizing simplified Monte Carlo calculation for patient specific QA of proton beam therapy Takahiro Yamada, Taisuke Takayanagi, Taeko Matsuura*1, Seishin Takao*1, Takaaki Yoshimura*1, Shusuke Hirayama, Takaaki Fujii*1, Kikuo Umegaki*1
Scientific Meeting of the Japan Society of Medical Physics Development of optimization method for patch irradiation technique by proton spot scanning Yusuke Fujii, Shinichiro Fujitaka, Masahiro Hosaka, Yoshihiko Nagamine, Kensuke Hayashi*2, Toshiyuki Toshito*2, Rintaro Fujimoto
Particle Accelerator Society of Japan OPTICAL DESIGN OF A HIGH ENERGY BEAM TRANSPORT FOR COMPACT PROTON BEAM THERAPY SYSTEMS Futaro Ebina, Takamichi Aoki, Yui Shinozawa
Particle Accelerator Society of Japan VARIABLE-ENERGY ACCELERATOR WITH LARGE CURRENT FOR PROTON BEAM THERAPY Chishin Hori, Takamichi Aoki, Takayoshi Seki
AAPM An analytical approach for calculating the dose-averaged LET in spot-scanning proton therapy with an input derived from a Monte Carlo simulation Shusuke Hirayama, Taeko Matsuura*1, Hideaki Ueda*1, Hidenori Koyano*1, Seishin Takao*1, Takaaki Fujii, Yusuke Fujii, Rintaro Fujimoto, Shinichi Shimizu*1, Kikuo Umegaki*1, Hiroki Shirato*1
Particle Accelerator Society of Japan STUDY OF GANTRY ANGLE DEPENDENCY OF BEAM SHAPE FOR PARTICLE BEAM THERAPY Takamichi Aoki, Futaro Ebina, Takahiro Yamada, Takuya Nomura, Satoshi Tootake
Particle Accelerator Society of Japan CONCEPT OF FREQUENCY MODULATED VARIABLE-ENERGY ACCELERATOR Takamichi Aoki, Toshimitsu Hae, Chishin Hori, Takayoshi Seki, Yuto Nakashima
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2016

Scientific Meeting of the Japan Society of Medical Physics A novel shape ridge filter for particle beam therapy Taisuke Takayanagi, Shinichiro Fujitaka, Rintaro Fujimoto, Chihiro Nakashima, Tomoki Murata, Chie Toramatsu*1, Taeko Matsuura*1, Kikuo Umegaki*1
PTCOG Development of ripple filters for particle beam therapy that are easier to manufacture Taisuke Takayanagi, Shinichiro Fujitaka, Rintaro Fujimoto, Chihiro Nakashima, Tomoki Murata, Chie Toramatsu*1, Taeko Matsuura*1, Kikuo Umegaki*1
AAPM Acceleration of dose optimization process using dual-loop optimization technique for spot scanning proton therapy Shusuke Hirayama, Rintaro Fujimoto
Particle Accelerator Society of Japan THE ANALYSIS OF CARBON BEHAVIOR WITH PARTICLE TRACKING FOR DECIDING OPERATION PATTERN OF RADIO-FREQUENCY ACCELERATING CAVITY IN A CARBON SYNCHROTRON Yuto Nakashima, Futaro Ebina
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2015

AAPM Development of an evaluation system to optimize synchrotron control during spot scanning proton therapy with multi-gated irradiations per operation cycle Takahiro Yamada, Naoki Miyamoto*1, Taeko Matsuura*1, Seishin Takao*1, Yuka Matsuzaki, Yusuke Fujii, Hidenori Koyano*1, Hideaki Nihongi, Masumi Umezawa, Koji Matsuda, Kikuo Umegaki*1, Hiroki Shirato*1
Scientific Meeting of the Japan Society of Medical Physics Proton dose calculation using a simplified Monte Carlo algorithm considering the effect of large angle scattering Taisuke Takayanagi, Shusuke Hirayama, Shinichiro Fujitaka, Masumi Umezawa
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

Contributions

2022

Physical Review Accelerator and Beams Concept of scanning magnet with distributed winding coils for particle beam therapy Takahiro Yamada, Kazuya Nagashima, Takuya Nomura, Seiji Soeda and Noriaki Hino
Medical Physics Deformed dose restoration to account for tumor deformation and position changes for adaptive proton therapy Koichi Miyazaki, Yusuke Fujii, Takahiro Yamada, Takahiro Kanehira*1, Naoki Miyamoto*1, Taeko Matsuura*1, Koichi Yasuda*1, Yusuke Uchinami*1, Manami Otsuka*1, Hidefumi Aoyama*1, and Seishin Takao*1
*1
Hokkaido University

2021

Journal of radiation research Validation of dose distribution for liver tumors treated with real-time-image gated spot-scanning proton therapy by log data based dose reconstruction Takahiro Yamada, Seishin Takao*1, Hidenori Koyano*1, Hideaki Nihongi, Yusuke Fujii, Shusuke Hirayama, Naoki Miyamoto*1, Taeko Matsuura*1, Kikuo Umegaki*1, Norio Katoh*1, Isao Yokota*1, Hiroki Shirato*1, Shinichi Shimizu*1
Journal of Applied Clinical Medical Physics Physical and biological beam modeling for carbon beam scanning at Osaka Heavy Ion Therapy Center Shinichiro Fujitaka, Yusuke Fujii, Hideaki Nihongi, Satoshi Nakayama, Masaaki Takashina*3, Noriaki Hamatani*3, Toshiro Tsubouchi*3, Masashi Yagi*3, Kazumasa Minami*3, Kazuhiko Ogawa*3, Junetsu Mizoe*3, Tatsuaki Kanai*3
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2020

Scientific reports On‑line range verifcation for proton beam therapy using spherical ionoacoustic waves with resonant frequency Taisuke Takayanagi, Tomoki Uesaka*1, Yuta Nakamura*1, Mehmet Burcin Unlu*1, Yasutoshi Kuriyama*5, Tomonori Uesugi*5, Yoshihiro Ishi*5, Nobuki Kudo*1, Masanori Kobayashi*6, Kikuo Umegaki*1, Satoshi Tomioka*1, Taeko Matsuura*1
Nuclear Inst. and Methods in Physics Research, A Evaluation of dispersion functions derived from fluctuation of the bending magnetic field of a synchrotron Futaro Ebina, Fumiaki Noda, Satoshi Totake, Takuya Nomura, Kento Miyahara, Noriyosu Hayashizaki
Journal of applied clinical medical physics Difference in LET‐based biological doses between IMPT optimization techniques: Robust and PTV‐based optimizations Shusuke Hirayama, Taeko Matsuura*1, Koichi Yasuda*1, Seishin Takao*1, Takaaki Fujii, Naoki Miyamoto*1, Kikuo Umegaki*1, Shinichi Shimizu*1
Academic journal “Accelerator” Vol.17, No.2 published by Particle Accelerator Society of Japan Development and Implementation of Compact Accelerator Systems Dedicated for Proton Beam Therapy Takamichi Aoki, Futaro Ebina
Hitachi Review Technology & Innovation Foresights 2020 Novel Variable-energy Accelerator for Particle Beam Therapy
https://www.hitachi.com/rev/archive/2020/r2020_03/24/index.html#sec01
Takamichi Aoki, Toshimitsu Hae, Takayoshi Seki, Yuto Nakashima, Chishin Hori
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2019

Scientific reports A novel range-verifcation method using ionoacoustic wave generated from spherical gold markers for particle-beam therapy: a simulation study Taisuke Takayanagi, Tomoki Uesaka*1, Masanori Kitaoka*1, Mehmet Burcin Unlu*1, Kikuo Umegaki*1, Hiroki Shirato*1, Lei Xing*1, Taeko Matsuura*1
Nuclear Inst. and Methods in Physics Research, A Variable-energy isochronous accelerator with cotangential orbits for proton beam therapy Chishin Hori, Takamichi Aoki, Takayoshi Seki
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2018

Medical Physics An analytical dose‐averaged LET calculation algorithm considering the off‐axis LET enhancement by secondary protons for spot‐scanning proton therapy Shusuke Hirayama, Taeko Matsuura*1, Hideaki Ueda*1, Yusuke Fujii, Takaaki Fujii*1, Seishin Takao*1, Naoki Miyamoto*1, Shinichi Shimizu*1, Rintaro Fujimoto, Kikuo Umegaki*1, Hiroki Shirato*1
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2017

Journal of applied clinical medical physics A simplified Monte Carlo algorithm considering large-angle scattering for fast and accurate calculation of proton dose Taisuke Takayanagi, Shusuke Hirayama, Shinichiro Fujitaka, Rintaro Fujimoto
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

2016

Physica Medica Optimization and evaluation of multiple gating beam delivery in a synchrotron-based proton beam scanning system using a real-time imaging technique Takahiro Yamada, Naoki Miyamoto*1, Taeko Matsuura*1, Seishin Takao*1, Yusuke Fujii, Yuka Matsuzaki, Hidenori Koyano*1, Masumi Umezawa, Hideaki Nihongi, Shinichi Shimizu*1, Hiroki Shirato*1, Kikuo Umegaki*1
Medical Physics Dual ring multilayer ionization chamber and theory-based correction technique for scanning proton therapy Taisuke Takayanagi, Hideaki Nihongi, Hideaki Nishiuchi, Masahiro Tadokoro, Yuki Ito, Chihiro Nakashima, Shinichiro Fujitaka, Masumi Umezawa, Koji Matsuda, Takeji Sakae*4, Toshiyuki Terunuma*4
Academic journal Vol. 136 No.5 published by The institute of electrical Engineers of Japan Development of a Compact Synchrotron for Proton Beam Therapy Futaro Ebina, Masumi Umezawa, Hideaki Nishiuchi, Takamichi Aoki, Kazuo Hiramoto, Koji Matsuda, Kikuo Umegaki*1, Michihiro Furusaka*1
Medical Physics Evaluation of the influence of double and triple Gaussian proton kernel models on accuracy of dose calculations for spot scanning technique Shusuke Hirayama, Taisuke Takayanagi, Yusuke Fujii, Rintaro Fujimoto, Shinichiro Fujitaka, Masumi Umezawa, Yoshihiko Nagamine, Masahiro Hosaka, Keisuke Yasui*2, Chihiro Omachi*2, Toshiyuki Toshito*2
*1
Hokkaido University
*2
Nagoya City University West Medical Center
*3
Osaka Heavy Ion Therapy Center
*4
University of Tsukuba
*5
Kyoto University
*6
Chiba Institute of Technology

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